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DeCS
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Descriptor English:
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Immunoglobulin Class Switching
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Descriptor Spanish:
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Cambio de Clase de Inmunoglobulina
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Descriptor Portuguese:
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Switching de Imunoglobulina
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Synonyms English:
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Class Switching
Isotype Switching
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Tree Number:
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G05.355.330.401.501.450
G12.425.742.500.501.450
G12.500.349.500.501.450
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Definition English:
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Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing. |
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History Note English:
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94
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Allowable Qualifiers English:
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Record Number:
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31391
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Unique Identifier:
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D017578
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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